Wuhan Han Sheng New Material Technology Co.，Ltd(expird)
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Country: 
China (Mainland)
Business Type:Trading Company
CAS NO.89226-75-5
| Molecular Formula | C35H40Cl2N4O6 |
| Molar Mass | 683.62 |
| Melting Point | 157-163°; mp 174-180°; mp 167-170° |
| Boling Point | 722°C at 760 mmHg |
| Flash Point | 390.4°C |
| Water Solubility | Soluble in DMSO. Slightly soluble in water and ethanol/n |
| Solubility | DMSO 21 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| Vapor Presure | 1.07E-20mmHg at 25°C |
| Appearance | solid |
| Color | White |
| Merck | 14,5743 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| In vitro study | At a sustained potential of − 37 mV, the calcium ion concentration response curve was inhibited by Ca manipine at concentrations above 0.1 nM. Manipine inhibited coronary and renal arteries with pIC50 of 9.3 nM and 9.1 nM, respectively. Manipipine partially inhibits sympathetic activity and inhibits the mean arterial pressure response to infusion of norepinephrine. Manidipin also inhibits aldosterone secretion. Manipipine increases urinary calcium and uric acid. In addition, manidipin, at nanomolar concentrations, is able to effectively regulate gene transcription involved in pro-inflammatory changes in mesangial cells. |
| In vivo study | Manidipine (3 mg/kg and 10 mg/kg, p.o.) dose-dependently reduced systolic blood pressure in three types of hypertensive rats. At a dose of 10 mg/kg, manipipine is able to reduce blood pressure to normal levels from 1 hour to 3 hours after administration; The antihypertensive effect lasts at least 8 hours. When manidipin was administered at 10 μg/kg, the hypotensive effect was significantly enhanced. Manidipin effectively inhibited the calcium ion flux induced by depolarization to 0 mV. However, a low concentration of manipine (1-3 nM) enhanced the flux of calcium ions induced by a -20 mV depolarizing pulse with a resting-state membrane potential of -80 mV. The inhibition of calcium ion flux by manidipin develops slowly and requires 10 minutes for maximum inhibition. |
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Wuhan Han Sheng New Material Technology Co. Ltd is a professional company which specialized in manufacturing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents.
We have long term cooperation pharmaceutical raw material production plant and a reagent research and development center, with a rich professional background and strong competitive advantage. We have a professional and experienced team and we promise clients to provide the best quality, price and service. During the business cooperation with clients, we always adhere principle of Honesty, Trustworthiness and win-win policy. We guarantee 100% qualification of our products pass through the standard of USA, Mexico, UK, Australia, Canada, Brazil, France, Germany, Spain, Belgium, Sweden, the Netherlands and so on.
Our products are used for pharmaceuticals, pesticides, synthetic dyes, organic chemicals, inorganic chemicals, coatings, spices and essence, cosmetics and toilet products, soaps and synthetic detergents, surfactants, printing inks and their auxiliaries, adhesives, photosensitive materials, magnetic materials, catalysts, reagents, water treatment agents and polymer flocculants, papermaking auxiliaries, leather auxiliaries, synthetic materials auxiliaries, textile printing and dyeing agents and finishing agents, food additives Feed additives, animal drugs, etc.
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