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Antiviral Powder Trifluridine CAS 70-00-8 For Anti-fection
Quick details of Trifluridine powder
Product Name: Trifluridine
Synonyms: 2,4(1h,3h)-pyrimidinedione,1-(2-deoxy-beta-d-ribofuranosyl)-5-(trifluorometh;Trifluridine (Viroptic);VIROPTIC; TRIFLUOROTHYMIDINE;Triflurdine (Viroptic);2'-deoxy-5-(trifluoromethyl)-uridin;5-(trifluoromethyl)deoxyuridine;5-trifluoro-2'-deoxythymidine;alpha,alpha,alpha-trifluoro-thymidin
CAS: 70-00-8
MF: C10H11F3N2O5
MW: 296.2
EINECS: 200-722-8
Product Categories: PARSOL;Antivirals for Research and Experimental Use;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Pharmaceutical Raw Materials;Pyrimidine series;API intermediates;Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides
Mol File: 70-00-8.mol
Trifluridine (trifluorothymidine, TFT), a fluorinated pyrimidine nucleoside, is an anti-herpesvirus agent and an antitumor antimetabolite agent. It is an analog of thymidine which inhibits thymidylate synthase possesses antiviral and anticancer activity. After phosphorylation by thymidine kinase, it is incorporated into DNA where it induces DNA-damage and interferes with repair enzymes. Enhances frame shift insertion and deletion in CRISPR genome editing in pluripotent stem cells.
Artemisinin and its semi-synthetic derivatives are a group of drugs used against Plasmodium falciparum malaria. Artemisinin is isolated from the plant Artemisia annua, sweet wormwood, a herb employed in Chinese traditional medicine. Chemically, artemisinin is a sesquiterpene lactonecontaining an unusual peroxide bridge. This peroxide is believed to be responsible for the drug's mechanism of action.
Items | Standards | Results | |
Appearance | White or off-white powder | Off-white powder | |
Identification | By HPLC | Complies | |
Melting Point | 120ºC~130ºC | 126ºC | |
Loss on Drying | ≤1.00% | 0.21% | |
Heavy Metals | ≤ 10ppm | Complies | |
Sulfated Ash | ≤ 0.10% | 0.03% | |
Content | 17.5%~19.5% | 19.3% | |
Content | ≤ 0.1ppm | 0.09ppm | |
Lead VContent | ≤ 3.0ppm | 0.50ppm | |
Content | ≤ 0.1ppm | 0.10ppm | |
Content | ≤ 0.1ppm | 0.10ppm | |
Microbiological Test | Coliforms:Negative | Negative | |
Salmonella: Negative | Complies | ||
Total plate count: ≤1000 CFU/g | Pass | ||
Yeast&Mold: ≤50 CFU/g | Pass | ||
Related Substances | Impurity A: ≤0.30% | 0.18% | |
Other unknown impurity: ≤0.10% | 0.07% | ||
Total Impurities: ≤0.50% | 0.42% | ||
Assay | ≥ 98.0% | 99.50% | |
Reference Standard | USP Standard | ||
Conclusion | The product complied to USP standard. | ||
Storage | Preserve in tight,light-resistant containers in a cool place |
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Wuhan Han Sheng New Material Technology Co. Ltd is a professional company which specialized in manufacturing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents.
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