China (Mainland)
Assessedsupplier 
Lower Price Deguelin CAS NO.522-17-8 CAS NO.522-17-8
- Min.Order: 10 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,MoneyGram,Other
- Product Details
Keywords
- Lower Price Deguelin CAS NO.522-17-8
- high quality Deguelin
- High purity Deguelin
Quick Details
- ProName: Lower Price Deguelin CAS NO.522-17-8
- CasNo: 522-17-8
- Molecular Formula: C23H22O6
- Appearance: White powder
- Application: Pharmaceuticals, pesticides, synthetic...
- DeliveryTime: 3-10 days
- PackAge: 1kg/Alu bag, 25kgs/Drum
- Port: Wuhan
- ProductionCapacity: 100 Metric Ton/Month
- Purity: 99%
- Storage: Dry and Cool Place and Keep Away From ...
- Transportation: *small quantity: By Fedex, DHL, HKPOST...
- LimitNum: 10 Kilogram
Superiority
Our Advantage:
- high quality with competitive price
- High quality standard: BP/USP/EP Enterprise standard
- All purity customized
- Fast and safe delivery
- We have reliable forwarder who can help us deliver our goods more fast and safe.
- We have stock and can deliver small quantity at once.
Details
Product Description：
| Molecular Formula | C23H22O6 |
| Molar Mass | 394.42 |
| Density | 1+-.0.06 g/cm3(Predicted) |
| Melting Point | 85-87°C(lit.) |
| Boling Point | 560.1±50.0 °C(Predicted) |
| Specific Rotation(α) | D27 -97.2° (c = 0.2 in benzene) |
| Solubility | DMSO : 50 mg/mL (126.77 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble) |
| Appearance | Form solid, color white to yellow |
| Color | white to yellow |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| MDL | MFCD01740600 |
| Physical and Chemical Properties | Bioactive Deguelin is a naturally occurring rotenone compound that acts as a chemoprevention agent by blocking various pathways such as PI3K-Akt,IKK-NF-κB and MAPK-mTOR-survivin. Binding of Deguelin to Hsp90 resulted in decreased expression of many oncogenic proteins, including MEK1/2,Akt,HIF1α,COX-2, and NF-κB. |
| In vitro study | Deguelin (0-500 nM) in a dose and time dependent manner inhibits the growth of MDA-MB-231, MDA-MB-468, BT-549 and BT-20 cells. Deguelin at all concentrations fails to reduce cell numbers in the presence of 1 ng EGF but in the presence of EGF 20 ng reinstated deguelin mediated growth inhibition. Deguelin treated cells show reduced expression of Survivin as determined by western blot and immunofluorescence examinations. Deguelin inhibits p-ERK and its downstream target p-STAT-3 and c-Myc expression in a dose dependent manner. Deguelin down-regulates Akt signaling probably by disrupting its association with Hsp 90 in cultured HNSCC cells. Deguelin deguelin disrupts the association between Hsp 90 with survivin and Cdk4. Deguelin deguelin treatment increases cellular ceramide level through de novo synthase pathway to mediate HNSCC cell death and apoptosis. Deguelin inhibits the proliferation of MPC-11 cells in a concentration- and time-dependent manner and causes the apoptotic death of MPC-11 cells. Following exposure to deguelin, the phosphorylation of Akt is decreased. Deguelin-induced apoptosis is characterized by the upregulation of Bax, downregulation of Bcl-2 and activation of caspase-3. |
| In vivo study | Deguelin (2 or 4 mg/kg, i.p.) reduces the in vivo tumor growth of MDA-MB-231 cells transplanted subcutaneously in athymic mice. Deguelin (4 mg/kg, p.o.) treatment shows a great inhibition in tumor growth, which is demonstrated by reduced tumor size and improved mice survival and, indicating a significant anti-tumor ability by deguelin in vivo. In the colon cancer xenograft model, the volume of the tumor treated with deguelin is significantly lower than that of the control, and the apoptotic index for deguelin-treated mice is much higher. |
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Company Profile：
Wuhan Han Sheng New Material Technology Co. Ltd is a professional company which specialized in manufacturing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents.
We have long term cooperation pharmaceutical raw material production plant and a reagent research and development center, with a rich professional background and strong competitive advantage. We have a professional and experienced team and we promise clients to provide the best quality, price and service. During the business cooperation with clients, we always adhere principle of Honesty, Trustworthiness and win-win policy. We guarantee 100% qualification of our products pass through the standard of USA, Mexico, UK, Australia, Canada, Brazil, France, Germany, Spain, Belgium, Sweden, the Netherlands and so on.
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Exhibitions:
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Products & Packaging：
Our products are used for pharmaceuticals, pesticides, synthetic dyes, organic chemicals, inorganic chemicals, coatings, spices and essence, cosmetics and toilet products, soaps and synthetic detergents, surfactants, printing inks and their auxiliaries, adhesives, photosensitive materials, magnetic materials, catalysts, reagents, water treatment agents and polymer flocculants, papermaking auxiliaries, leather auxiliaries, synthetic materials auxiliaries, textile printing and dyeing agents and finishing agents, food additives Feed additives, animal drugs, etc.
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About Us
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Shipment & Payment：
*small quantity: By Fedex, DHL, HKPOST, UPS, TNT or As customers’ requirement
*Bulk order: By air or sea
*Delivery: within 3 days for samples and 10 days for bulk order
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Our Markets:
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FAQ
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Are you a trade company or factory
We are a factory with our own trading company.
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How do you control the quality
Our factory is equipped with professional technicians to inspect the quality around production lines. The inspection test would be made every 2 hours to ensure the production conform to quality standard. We also accept BV, SGS, or any third pary inspection.
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How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
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Where is your factory located How can I visit the factory
Our factory located in Hebei, China
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Can I get some samples
Yes, we can supply sample with free, but the shipping cost be paid by our customers.
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How to start orders or make payments
Proforma Invoice will be issued first after confirmation of order, enclosed our bank information. Payment could be done by T/T or .
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How to confirm the product quality before placing order
You can get free samples for some products. You only need to pay the shipping cost or arrange a courier to us and take the samples.
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How do you treat quality complaint