Wuhan Han Sheng New Material Technology Co.，Ltd(expird)
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CAS NO.20283-92-5
| Product Name: | Rosmarinic acid |
| CAS: | 20283-92-5 |
| MF: | C18H16O8 |
| MW: | 360.31 |
| EINECS: | 606-487-1 |
| Melting point | 171-175 °C (lit.) |
| alpha | +102～+110°(D/20℃)(c=0.2,C2H5OH) |
| Boiling point | 694.7±55.0 °C(Predicted) |
| density | 1.33 |
| storage temp. | 2-8°C |
| solubility | Soluble in ethanol, DMSO or dimethyl formamide to approximately 25 mg/mL. |
| form | powder |
| pka | 2.78±0.10(Predicted) |
| color | white to faintly beige |
| BRN | 2227587 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
1. Rosmarinic acid is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid. It is commonly found in species of the Boraginaceae and the subfamily Nepetoideae of the Lamiaceae. However, it is also found in species of other higher plant families and in some fern and hornwort species. Rosmarinic acid has a number of interesting biological activities, e.g. antiviral, antibacterial, antiinflammatory and antioxidant. The presence of rosmarinic acid in medicinal plants, herbs and spices has beneficial and health promoting effects. In plants, rosmarinic acid is supposed to act as a preformed constitutively accumulated defence compound.[sciencedirect]
2. Rosmarinic acid (RA) is one example of a naturally occurring phenolic compound in plants. RA is especially high in Salvia officinalis (garden sage). As an antioxidant, RA possesses both health benefits, and is useful as a food additive to keep foods fresh.Recently, Bakota et al. successfully prepared an extract of Salvia officinalis at three times the levels from sage leaves alone.[thermofisher]
3. Rosmarinic Acid is a phenylpropanoid isolated from Labiatae herbs. The compound exhibits antiinflammatory activity and inhibits the proliferation of murine mesangial cells. Rosmarinic Acid has been shown to dose dependently inhibit migration, adhesion, and invasion of Ls174-T human colon carcinoma cells. Rosmarinic Acid has been documented to increase the melanin content in B16 melanoma cells through activation of protein kinase A. In the same study rosmarinic acid induced the phosphorylation of CRE-binding protein (CREB) and activated cAMP response element (CRE). In the classical complement pathway Rosmarinic Acid inhibited C3-convertase. It also has shown to be an activator of GPR35.[Santa Cruz]
4. Rosmarinic acid is a naturally-occurring phenolic compound with antioxidant and anti-inflammatory properties. This compound inhibits lipid peroxidation of rat liver microsomes by 90% at a concentration of 25 µg/ml.Rosmarinic acid suppresses endotoxin-induced activation of complement and concomitant formation of prostacyclin.Formation of 5-HETE and LTB from human PMNL is inhibited by rosmarinic acid at concentrations of 10-5 to 10-3 M. [caymanchem]
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Wuhan Han Sheng New Material Technology Co. Ltd is a professional company which specialized in manufacturing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents.
We have long term cooperation pharmaceutical raw material production plant and a reagent research and development center, with a rich professional background and strong competitive advantage. We have a professional and experienced team and we promise clients to provide the best quality, price and service. During the business cooperation with clients, we always adhere principle of Honesty, Trustworthiness and win-win policy. We guarantee 100% qualification of our products pass through the standard of USA, Mexico, UK, Australia, Canada, Brazil, France, Germany, Spain, Belgium, Sweden, the Netherlands and so on.
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