Wuhan Han Sheng New Material Technology Co.，Ltd(expird)
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Business Type:Trading Company
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Country: 
China (Mainland)
Business Type:Trading Company
CAS NO.1104-22-9
| Molecular Formula | C25H29Cl3N2 |
| Molar Mass | 463.87 |
| Melting Point | 210.0 to 214.0 °C |
| Boling Point | 495.3°C at 760 mmHg |
| Flash Point | 253.3°C |
| Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Vapor Presure | 6E-10mmHg at 25°C |
| Appearance | White, slightly yellowish, crystalline powder |
| Color | white to beige |
| Storage Condition | 2-8°C |
| In vitro study | Meclizine is a histamine H1 receptor antagonist used in the treatment of Nausea and motion sickness with anticholinergic, central nervous system depressant and local anesthetic effects. Meclizine is a mouse CAR agonist ligand (constitutive androstane receptor), an inverse agonist of the human CAR. In vitro experiments, Meclizine dose-dependently increased mCAR transactivation, activating the binding of hormone receptor coactivator 1 to the receptor. In contrast, in mouse-derived liver cells that express only hCAR but do not express mCAR, meclizine inhibits transcriptional activation of hCAR and Lumina-induced CAR downstream genes, including the expression of cytochrome p450 monooxygenase (CYP)2B10,CYP3A11, and CYP1A2. |
| In vivo study | Treatment of mice with Meclizine increased CAR target gene expression in a CAR-dependent manner. In the mouse polyQ toxicity cell model, Meclizine reduces oxidative metabolism and inhibits apoptotic cell death. |
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Wuhan Han Sheng New Material Technology Co. Ltd is a professional company which specialized in manufacturing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents.
We have long term cooperation pharmaceutical raw material production plant and a reagent research and development center, with a rich professional background and strong competitive advantage. We have a professional and experienced team and we promise clients to provide the best quality, price and service. During the business cooperation with clients, we always adhere principle of Honesty, Trustworthiness and win-win policy. We guarantee 100% qualification of our products pass through the standard of USA, Mexico, UK, Australia, Canada, Brazil, France, Germany, Spain, Belgium, Sweden, the Netherlands and so on.
Our products are used for pharmaceuticals, pesticides, synthetic dyes, organic chemicals, inorganic chemicals, coatings, spices and essence, cosmetics and toilet products, soaps and synthetic detergents, surfactants, printing inks and their auxiliaries, adhesives, photosensitive materials, magnetic materials, catalysts, reagents, water treatment agents and polymer flocculants, papermaking auxiliaries, leather auxiliaries, synthetic materials auxiliaries, textile printing and dyeing agents and finishing agents, food additives Feed additives, animal drugs, etc.
About Us
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*small quantity: By Fedex, DHL, HKPOST, UPS, TNT or As customers’ requirement
*Bulk order: By air or sea
*Delivery: within 3 days for samples and 10 days for bulk order