Wuhan Han Sheng New Material Technology Co.，Ltd(expird)
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CAS NO.74431-23-5
| Name | (6R,7R)-7-AMIMO-8-OXO-3-(1-PROPENYL)-5-THIA-1-azabicyclo[4.2.0]OCT-2-ene-2-carboxylic acid monohydrate |
| Synonyms | Imipenem hydrate Imipenem monohydrate (6R,7R)-7-AMIMO-8-OXO-3-(1-PROPENYL)-5-THIA-1-azabicyclo[4.2.0]OCT-2-ene-2-carboxylic acid monohydrate 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid,6-(1-hydroxyethyl)-3-[[2-(iminomethyl)amino]ethyl]thio]-7-oxo-,monohydrate (5R,6S)-3-[(2-{[(1E)-aminomethylidene]amino}ethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate |
| CAS | 74431-23-5 |
| EINECS | 264-734-5 |
| InChI | InChI=1/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1 |
| Molecular Formula | C16H25N2O5S.C12H18N4O4.Na |
| Molar Mass | 662.74 |
| Melting Point | 193-198°C |
| Boling Point | 567.3°C at 760 mmHg |
| Flash Point | 296.9°C |
| Water Solubility | Soluble in water at 5mg/ml |
| Vapor Presure | 3.11E-15mmHg at 25°C |
| Appearance | Shape powder, color white to beige |
| pKa | pKa 3.2/9.9(H2O,t = 25) (Uncertain) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Physical and Chemical Properties | Chemical properties crystallize from water-ethanol. [α]D23 +86.8 (C = 0.05,0.1mol/L, phosphate buffer, Ph = 7). PKal is about 3.2 and pKa2 is about 9.9. UV maximum absorption (water):299nm(ε9670,98% hydroxylamine extraction). Solubility (mg/m1): water 10, methanol 5, ethanol 0.2, acetone <0.1, dimethylformamide <0.1, dimethyl sulfoxide 0.3. |
| Use | Uses carbapenem extended-spectrum β-lactam antibiotics, is a semi-synthetic derivative of thiomycin, antibacterial spectrum and the role of use and thiomycin similar, but more stable than thiomycin. And other antibiotics are not cross-resistant, but vulnerable to renal peptidase destruction, and renal peptidase inhibitors (such as cilastatin sodium) is often used. Stable to beta-lactamase. For urinary tract infections, lower respiratory tract infections, intra-abdominal infections, skin and soft tissue infections, digestive system infections, osteomyelitis, prostatitis, bacteremia. |
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Wuhan Han Sheng New Material Technology Co. Ltd is a professional company which specialized in manufacturing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents.
We have long term cooperation pharmaceutical raw material production plant and a reagent research and development center, with a rich professional background and strong competitive advantage. We have a professional and experienced team and we promise clients to provide the best quality, price and service. During the business cooperation with clients, we always adhere principle of Honesty, Trustworthiness and win-win policy. We guarantee 100% qualification of our products pass through the standard of USA, Mexico, UK, Australia, Canada, Brazil, France, Germany, Spain, Belgium, Sweden, the Netherlands and so on.
Our products are used for pharmaceuticals, pesticides, synthetic dyes, organic chemicals, inorganic chemicals, coatings, spices and essence, cosmetics and toilet products, soaps and synthetic detergents, surfactants, printing inks and their auxiliaries, adhesives, photosensitive materials, magnetic materials, catalysts, reagents, water treatment agents and polymer flocculants, papermaking auxiliaries, leather auxiliaries, synthetic materials auxiliaries, textile printing and dyeing agents and finishing agents, food additives Feed additives, animal drugs, etc.
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