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Country: China (Mainland)
Business Type:Trading Company
CAS NO.15687-27-1
A common goal in the development of pain and inflammation medicines has been the creation of compounds that have the ability to treat inflammation, fever, and pain without disrupting other physiological functions. General pain relievers, such as aspirin and ibuprofen, inhibit both COX-1 and COX-2. A medication's specificaction toward COX-1 versus COX-2 determines the potential for adverse side effects. Medications with greater specificity toward COX-1 will have greater potential for producing adverse side effects. By deactivating COX-1, nonselective pain relievers increase the chance of undesirable side effects, especially digestive problems such as stomach ulcers and gastrointestinal bleeding. COX-2 inhibitors, such as Vioxx and Celebrex, selectively deactivate COX-2 and do not aff ect COX-1 at prescribed dosages. COX-2 inhibitors are widely prescribed for arthritis and pain relief. In 2004, the Food and Drug Administration (FDA) announced that an increased risk of heart attack and stroke was associated with certain COX-2 inhibitors. This led to warning labels and voluntary removal of products from the market by drug producers; for example, Merck took Vioxx off the market in 2004. Although ibuprofen inhibits both COX-1 and COX-2, it has several times the specificity toward COX-2 compared to aspirin, producing fewer gastrointestinal side effects.
Product Name: | Ibuprofen |
CAS: | 15687-27-1 |
MF: | C13H18O2 |
MW: | 206.28 |
EINECS: | 239-784-6 |
Melting point | 77-78 °C |
Boiling point | 157 °C (4 mmHg) |
alpha | [α]D20 -1~+1°(c=1,C2H5OH) |
density | 1.0364 (rough estimate) |
refractive index | 1.5500 (estimate) |
Fp | 9℃ |
storage temp. | 2-8°C |
pka | pKa 4.45± 0.04(H2O,t = 25±0.5,I=0.15(KCl))(Approximate) |
form | Crystalline Powder |
color | white to off-white |
Water Solubility | insoluble |
Merck | 14,4881 |
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Wuhan Han Sheng New Material Technology Co. Ltd is a professional company which specialized in manufacturing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents.
We have long term cooperation pharmaceutical raw material production plant and a reagent research and development center, with a rich professional background and strong competitive advantage. We have a professional and experienced team and we promise clients to provide the best quality, price and service. During the business cooperation with clients, we always adhere principle of Honesty, Trustworthiness and win-win policy. We guarantee 100% qualification of our products pass through the standard of USA, Mexico, UK, Australia, Canada, Brazil, France, Germany, Spain, Belgium, Sweden, the Netherlands and so on.
Our products are used for pharmaceuticals, pesticides, synthetic dyes, organic chemicals, inorganic chemicals, coatings, spices and essence, cosmetics and toilet products, soaps and synthetic detergents, surfactants, printing inks and their auxiliaries, adhesives, photosensitive materials, magnetic materials, catalysts, reagents, water treatment agents and polymer flocculants, papermaking auxiliaries, leather auxiliaries, synthetic materials auxiliaries, textile printing and dyeing agents and finishing agents, food additives Feed additives, animal drugs, etc.
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